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By Levels, Committee On Acute Exposure Guideline

ISBN-10: 0309283086

ISBN-13: 9780309283083

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0 μm. The experiments were conducted using a series of suspensions and solutions of BZ, including an acetone solution, Freon 11 suspension, methylene chloride solution, pyrotechnic mix, and water solution. For the pyrotechnic mix (eight volunteers), breathing was regulated by reference to a visual feedback system that resulted in more uniform (± 10%) ventilation rates and tidal volumes. 5. Probit analysis for exposures associated with various TRI indices was reported by Ketchum (1963). The analysis provided an ED50 (a concentrationtime product causing a specific TRI score in 50% of the test subjects) with 95% confidence limits for aerosol exposures (see Table 1-3) for groups of 36 volunteers.

40 500 No effects. 164 8 min 32°F, 63% relative humidity a All effects occurring in dogs at any time during the post-exposure observation period are noted, although not all dogs exhibited all effects. b Study report indicated “no samples”. Source: Ketchum et al. 1967. TABLE 1-7 Effects of Agent BZ on Rabbits Concentration (mg-min/m3) 575 Duration 6 min, 10 sec Conditions 41°F, 67% relative humidity Distance (yards) 100 Effectsa Mydriasis, cycloplegia. No datab 500 Mydriasis, cycloplegia, salivation.

Uncertainty factors: 10 for interspecies differences; no lethality data are available for humans and LCt50 values for five animal species varied 10-fold. 10 for intraspecies variability; BZ toxicity is due to an anticholinergic mechanism and the structures of muscarinic receptors are highly conserved in humans, so receptor affinity (and, therefore, toxicodynamics) is not likely to vary among individuals; however, some individuals with pre-existing conditions may be sensitive to the anticholinergic effects of BZ.

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Acute exposure guideline levels for selected airborne chemicals : volume 14. by Levels, Committee On Acute Exposure Guideline

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