By P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)
P. Denoix and G. Mathe nearly 70% of melanoma sufferers relapse after surgical procedure sooner than the fifth yr and, often, for instance in breast carcinoma, they relapse nonetheless later as much as the twentieth yr. For a few huge time, the method of melanoma therapy has been constrained to the sophistication of surgery-radiotherapy mixtures that maximally lowered the prevalence of neighborhood and nearby relapses in websites that have been inside their succeed in. this present day, the perform of medical oncology is unthinkable with no the energetic participation of the scientific oncologist. he's the "third guy" of the medical oncology staff, and he has lately targeted awareness at the indisputable fact that so much relapses come up from far-off metastases a result of proliferation of cells seeded there after having left the first tumor web site on the time of operation and, for this reason, are inaccessible to any shape oflocal and/or neighborhood therapy. in this facts, scientific oncologists have proposed the applying of scientific remedies for disseminated minimum residual affliction (MRD). they've got to be had ability: chemother apy and immunotherapy. scientific oncologists ordinarily should be divided into 3 teams: chemotherapists, immunotherapists, and chemoimmunotherapists. The natural chemotherapists, who had already cured a few malignant neoplasias resembling Hodgkin's sickness, acute lymphoid leukemia, placental choriocarcinoma, and Wilms' tumor, suggestion they may have the technique of attacking the residual disorder of universal cancers.
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Additional resources for Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies
Recurrence-free rate as a function of time from diagnosis for primary operable patients by level of postoperative plasma CEA levels. 9% of the node-negative patients. In the node X (where nodal status was not known), CEAs were found to be elevated in 23% of cases. We have now followed the primary cases for a mean period of 705 days from diagnosis. The association of postoperative CEA levels with recurrence for all operable patients is shown in Fig. 2. The numbers at the top of the curves represent the actual numbers of patients followed to a given time.
6 and submitted to chromatography on DEAE cellulose. All the different protein peaks are obtained by stepwise elution as shown in Fig. 1. The hormonal dependance of some breast cancers and the intracellular secretary products suggest the synthesis of milk-like substances. It was then proposed that some mammary carcinomas could produce milk antigens. We have tried to clarify the problem of caseins in human breast cancer. With this objective we initiated radioimmunoassays of caseins in 1973 . Our first results were obtained with a system using whole casein as tracer and standard.
Fig. 5. l. (1977) Oct. Nov. Dec. (1978) Feb. Mar. Apr. ---Surgery ng/ml 10' T'' Y \ 10 Fig. 6. Testis yolk sac tumor (case 5) 37 \ • ---------- 1971, -------------------------- 1975 Case 5. A yolk sac tumor of the testis was detected in a 13 month old boy. At 6 months of age, a left testis enlargement was observed and a hydrocele testis was diagnosed. In 1974 an operation was performed and a tumor was discovered. The aFP, tested the day after surgery, was abnormal. It was still abnormal 3 weeks later, being over 200 ng/ml.
Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies by P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)